Reference intervals

ri = reference_interval(values; method=:nonparametric)
partitions = assess_partitions(data; group=:age_group)
curve = reference_curve(age, values)

Nonparametric limits follow the 2.5th–97.5th percentile convention of CLSI EP28 (Clinical and Institute, 2010). Also available: parametric, robust MAD, log-transformed, Box–Cox (Box and Cox, 1964), Horn's Tukey-filter procedure (Horn et al., 1998), and Cole LMS (Cole and Green, 1992). Bootstrap confidence intervals are optional.

assess_partitions implements Harris–Boyd style evidence (Harris and Boyd, 1990) and does not recommend clinical partitions.

reference_curve estimates local quantiles against a continuous covariate instead of forcing bins. method=:lms uses a global Box–Cox λ with local μ and σ (Cole LMS-style).